Glycophorin A GpA is a protein found in the human membrane red blood cell. The GpA gene bears the antigenic determinants for the MN and Ss blood groups, and 40 related variants of the Miltenberger complex and several isoforms of Sta1. There are two classes of membrane glycoproteins, asialo and sialoglycoproteins glycophorins. These glycoproteins are determined by the presence of sialic acid which is the negative charge on cell surface. GpA is the primary sialoglycoprotein of human erythrocyte membranes that forms noncovalent dimers by sequence-specific, reversible association of its single hydrophobic membrane-spanning domain2. The glycophorin …show more content… The glycosylated part of the N-terminus acts as receptors of MN blood group.
Anemia Decreases the Number of Red Blood Cells Essay
Anemia Decreases the Number of Red Blood Cells Essay | Bartleby
Red Blood Cells Red blood cells will change shape in response to the evolving environment. For instance when distilled water is added to red blood cells, the red blood cells seem to expand. Why does this natural phenomenon cause red blood cells to appear considerably bigger after being exposed to distilled water? We tested two theories of why this happens. Theorem one is that molecules such as protein and polysaccharides are more concentrated inside the cell than outside the cell when the cell is.
Red Blood Cells Importance
It forms a sickle looking shape red blood cells. The main cause of Sickle Cell Anemia is from the mutation of a protein called Hemoglobin. There are four protein subunits or parts which are two subunits of alpha globin and two subunits of beta globin.
Anemia is not considerate to be a specific disease; it is a manifestation of many abnormal conditions. Some of the abnormal conditions that causes anemia include dietary deficiencies of iron, vitamin B12, and folic acid; hereditary disorders; bone marrow damaged by toxins, radiation, or chemotherapy; renal disease; malignancy; chronic infection; overactive spleen; or bleeding from a tract or organ. The incidence of anemia in the world is very high.